Intraovarian Control of Early Folliculogenesis
نویسندگان
چکیده
منابع مشابه
Intraovarian control of early folliculogenesis.
Although hormonal regulation of ovarian follicle development has been extensively investigated, most studies concentrate on the development of early antral follicles to the preovulatory stage, leading to the successful use of exogenous FSH for infertility treatment. Accumulating data indicate that preantral follicles are under stringent regulation by FSH and local intraovarian factors, thus pro...
متن کاملEpigenetic control of folliculogenesis and luteinization
Folliculogenesis and luteinization are characterized by irreversible and profound physiological and morphological transformation processes, which eventually culminate in the provision of fertilizable eggs and the conversion of the estrogen producing follicle into a progesterone producing corpus luteum. All these processes are preceded by complex alterations of the gene expression profiles in th...
متن کاملIntraovarian regulation of gonadotropin-dependent folliculogenesis depends on notch receptor signaling pathways not involving Delta-like ligand 4 (Dll4)
BACKGROUND In-situ hybridisation studies demonstrate that Notch receptors and ligands are expressed in granulosa cells (GCs) and in the theca layer vasculature of growing follicles. Notch signaling involves cell-to-cell interaction mediated by transmembrane receptors and ligands. This signaling pathway may represent a novel intraovarian regulator of gonadotropin-dependent follicular development...
متن کاملIntraovarian actions of oestrogen.
Oestrogen regulates several hypothalamic and pituitary hormones, which in turn control ovarian functions. Oestrogen and its metabolites, such as catecholoestrogens, also have direct effects within the ovary. This review examines the roles of oestrogen in regulating ovarian folliculogenesis, ovulation and corpus luteum formation. Oestrogen promotes follicular development, which culminates in ovu...
متن کاملNOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression.
Primordial ovarian follicles in mice form when somatic cells surround individual oocytes. We show that lack of Nobox, an oocyte-specific homeobox gene, accelerates postnatal oocyte loss and abolishes the transition from primordial to growing follicles in mice. Follicles are replaced by fibrous tissue in female mice lacking Nobox in a manner similar to nonsyndromic ovarian failure in women. Gene...
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ژورنال
عنوان ژورنال: Endocrine Reviews
سال: 2015
ISSN: 0163-769X,1945-7189
DOI: 10.1210/er.2014-1020